Reactome: A Curated Pathway Database
The EBI data centre will be shutting down from the afternoon (BST) of Friday 26th August until the afternoon of Tuesday 30th August 2016 for essential maintenance. This might have an impact on some Reactome services and we apologize for any inconvenience.

ATP Hydrolysis By Myosin

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

The cleft closes like a clam shell around the ATP molecule, triggering a large shape change that causes the myosin head to release actin and be displaced along the actin filament by a distance of about 5 nm. Hydrolysis of ATP occurs, but the ADP remains tightly bound to the protein.

Literature References
PubMed ID Title Journal Year
10747208 Regulation of contraction in striated muscle Physiol Rev 2000
Regulatory Mechanisms of Striated Muscle Contraction Advances in Experimental Medicine and Biology 2007
Participant Of
This entity is regulated by:
Title Physical Entity Activity
myosin phosphatase activity of Myosin Complex [cytosol] Myosin Complex [cytosol] myosin phosphatase activity (0017018)
Orthologous Events