ATP Hydrolysis By Myosin

Stable Identifier
R-HSA-390593
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The cleft closes like a clam shell around the ATP molecule, triggering a large shape change that causes the myosin head to release actin and be displaced along the actin filament by a distance of about 5 nm. Hydrolysis of ATP occurs, but the ADP remains tightly bound to the protein.

Literature References
PubMed ID Title Journal Year
  Regulatory Mechanisms of Striated Muscle Contraction   2007
10747208 Regulation of contraction in striated muscle Physiol Rev 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
myosin phosphatase activity of Myosin Complex [cytosol]
Physical Entity
Activity
Orthologous Events