Reactome: A Curated Pathway Database
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ATP Hydrolysis By Myosin

Stable Identifier
R-HSA-390593
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The cleft closes like a clam shell around the ATP molecule, triggering a large shape change that causes the myosin head to release actin and be displaced along the actin filament by a distance of about 5 nm. Hydrolysis of ATP occurs, but the ADP remains tightly bound to the protein.

Literature References
PubMed ID Title Journal Year
10747208 Regulation of contraction in striated muscle Physiol Rev 2000
Regulatory Mechanisms of Striated Muscle Contraction Advances in Experimental Medicine and Biology 2007
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
myosin phosphatase activity of Myosin Complex [cytosol] Myosin Complex [cytosol] myosin phosphatase activity (0017018)
Orthologous Events