The cleft closes like a clam shell around the ATP molecule, triggering a large shape change that causes the myosin head to release actin and be displaced along the actin filament by a distance of about 5 nm. Hydrolysis of ATP occurs, but the ADP remains tightly bound to the protein.
|Myosin Complex||myosin phosphatase activity (0017018)|
|10747208||Regulation of contraction in striated muscle||Physiol Rev||2000|
|Regulatory Mechanisms of Striated Muscle Contraction||Advances in Experimental Medicine and Biology||2007|