Reactome: A Curated Pathway Database

ATP Hydrolysis By Myosin (R-HSA-390593) [Homo sapiens]


The cleft closes like a clam shell around the ATP molecule, triggering a large shape change that causes the myosin head to release actin and be displaced along the actin filament by a distance of about 5 nm. Hydrolysis of ATP occurs, but the ADP remains tightly bound to the protein.

Additional Information
Compartment cytosol
Catalyst Activity
PhysicalEntity Activity Active Units
Myosin Complex myosin phosphatase activity (0017018)
Literature References
pubMedId Title Journal Year
10747208 Regulation of contraction in striated muscle Physiol Rev 2000
Regulatory Mechanisms of Striated Muscle Contraction Advances in Experimental Medicine and Biology 2007