Reactome: A Curated Pathway Database

Release Of ADP From Myosin

Stable Identifier
R-HSA-390597
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The weak binding of the myosin head to the new site on the actin filament causes release of the inorganic phosphate produced by ATP hydrolysis, concomitantly with the tight binding of the head to actin. This release triggers the power stroke, a force-generating change in the shape during which the head regains its original conformation. In the course of the power stroke, the head loses its bound ADP, thereby returning to the start of a new cycle.

Literature References
PubMed ID Title Journal Year
10747208 Regulation of contraction in striated muscle Physiol Rev 2000
Regulatory Mechanisms of Striated Muscle Contraction Advances in Experimental Medicine and Biology 2007
Participants
Participant Of
Orthologous Events