Reactome: A Curated Pathway Database

Myosin Binds ATP (R-HSA-390598) [Homo sapiens]


A molecule of ATP binds to the large cleft on the side of the myosin head farthest from the actin filament and immediately causes a slight change in the conformation of the domains that make up the actin-binding site. This reduces the affinity of the myosin head for actin and allows it to move along the filament.

Additional Information
Compartment cytosol
Literature References
pubMedId Title Journal Year
10747208 Regulation of contraction in striated muscle Physiol Rev 2000
Regulatory Mechanisms of Striated Muscle Contraction Advances in Experimental Medicine and Biology 2007