Reactome: A Curated Pathway Database
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SIRP alpha binds CD47

Stable Identifier
R-HSA-391158
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CD47 is an extracellular ligand for SIRP alpha. SIRP alpha directly binds to the loops of the Ig variable like domain of CD47 in an end-to-end fashion. The SIRP alpha/CD47 interaction is unusual in that it can lead to bidirectional signaling through SIRP alpha and CD47. The major function of this interaction is prevention of phagocytosis of RBC and platelets by macrophages.

Literature References
Participants
Participant Of
Orthologous Events