Reactome: A Curated Pathway Database

Adrenaline signalling through Alpha-2 adrenergic receptor (R-HSA-392023)

Species Homo sapiens

Summation

Adrenaline (epinephrine) signalling via the alpha-2 adrenergic receptor has many effects including inhibition of insulin release in pancreas, iinduction of glucagon release from pancreas, contraction of sphincters of the gastrointestinal tract, negative feedback processes in neuronal synapses and stimulation of platelet aggregation. This receptor preferentially couples to members of the Gi class of heterotrimeric G-proteins, leading to inhibition af adenylate cyclase and thereby decreased cAMP levels.

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane
Cross References
Database Identifier
BioModels Database BIOMD0000000082, BIOMD0000000080
Literature References
pubMedId Title Journal Year
2823383 Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor Science 1987