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G beta:gamma signalling through PI3Kgamma

Stable Identifier
R-HSA-392451
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PI3K gamma (PI3KG) is a heterodimer consisting of a p110 catalytic subunit associated with a regulatory p101 or p84 subunit. PI3KG is most highly expressed in neutrophils, where the p101 form predominates (approximately 95%). G beta:gamma recruits PI3KG to the plasma membrane, both activating PI3KG and providing access to its substrate PIP2, which is converted to PIP3.

Participants
Participant Of
Orthologous Events