PI3K gamma (PI3KG) is a heterodimer consisting of a p110 catalytic subunit associated with a regulatory p101 or p84 subunit. PI3KG is most highly expressed in neutrophils, where the p101 form predominates (approximately 95%). G beta:gamma recruits PI3KG to the plasma membrane, both activating PI3KG and providing access to its substrate PIP2, which is converted to PIP3.
|BioModels Database||BIOMD0000000175, BIOMD0000000088, BIOMD0000000137, BIOMD0000000424, BIOMD0000000255|
|17916723||PI3Kgamma is a key regulator of inflammatory responses and cardiovascular homeostasis||Science||2007|
|17041586||Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils||Nat Cell Biol||2006|