Reactome: A Curated Pathway Database

G-protein beta:gamma signalling (R-HSA-397795) [Homo sapiens]


The classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known that Gbeta/gamma subunits can directly modulate many effectors, including some also regulated by G alpha.

Additional Information
Compartment plasma membrane
Literature References
pubMedId Title Journal Year
18834311 The Role of Gbetagamma Subunits in the Organization, Assembly, and Function of GPCR Signaling Complexes Annu Rev Pharmacol Toxicol 2008