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G-protein beta:gamma signalling

Stable Identifier
R-HSA-397795
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known that Gbeta/gamma subunits can directly modulate many effectors, including some also regulated by G alpha.

Literature References
PubMed ID Title Journal Year
18834311 The Role of Gbetagamma Subunits in the Organization, Assembly, and Function of GPCR Signaling Complexes Annu Rev Pharmacol Toxicol 2008
Participants
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