There will be a maintenance on OICR IT systems starting Friday Dec 15 at 6PM EST until midnight Sunday Dec 17; Reactome will be affected by this downtime

Service under maintenance from Friday Dec 15 at 6PM EST until midnight Sunday Dec 17

Trafficking of AMPA receptors

Stable Identifier
R-HSA-399719
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Repetitive presynaptic activity causes long lasting changes in the postsynaptic transmission by changing the type and the number of AMPA receptors. These changes are brought about by trafficking mechanisms that are mainly controlled by activity dependent phosphorylation/desphosphorylation of the GluR1/GluR2 subunits.

Literature References
PubMed ID Title Journal Year
19217372 Synaptic AMPA receptor plasticity and behavior Neuron 2009
Participants
Participant Of
Orthologous Events