Reactome: A Curated Pathway Database

SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

Stable Identifier
R-HSA-399955
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Sema3A, a prototypical semaphorin, acts as a chemorepellent or a chemoattractant for axons by activating a receptor complex comprising neuropilin-1 as the ligand-binding subunit and plexin-A1 as the signal-transducing subunit. Sema3A inhibits cell migration by inhibiting integrin ligand-binding activity.

Literature References
Participants
Participant Of
Orthologous Events