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CRMPs in Sema3A signaling

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

CRMPs are a small family of plexinA-interacting cytosolic phosphoproteins identified as mediators of Sema3A signaling and neuronal differentiation. After Sema3A activation Plexin-A bound CRMP's undergo phosphorylation by Cdk5, GSK3beta and Fes kinases. Phosphorylation of CRMPs by these kinases blocks the ability of CRMP to bind to tubulin dimers, subsequently induces depolymerization of F-actin, and ultimately leads to growth cone collapse.

Literature References
PubMed ID Title Journal Year
17607942 The CRMP family of proteins and their role in Sema3A signaling Adv Exp Med Biol 2007
Participant Of
Orthologous Events