Reactome: A Curated Pathway Database

CRMPs in Sema3A signaling (R-HSA-399956)

Species Homo sapiens

Summation

CRMPs are a small family of plexinA-interacting cytosolic phosphoproteins identified as mediators of Sema3A signaling and neuronal differentiation. After Sema3A activation Plexin-A bound CRMP's undergo phosphorylation by Cdk5, GSK3beta and Fes kinases. Phosphorylation of CRMPs by these kinases blocks the ability of CRMP to bind to tubulin dimers, subsequently induces depolymerization of F-actin, and ultimately leads to growth cone collapse.

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Literature References
pubMedId Title Journal Year
17607942 The CRMP family of proteins and their role in Sema3A signaling Adv Exp Med Biol 2007