Reactome: A Curated Pathway Database

Ca2+ pathway

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

A number of so called non-canonical WNT ligands have been shown to promote intracellular calcium release upon FZD binding. This beta-catenin-independent WNT pathway acts through heterotrimeric G proteins and promotes calcium release through phophoinositol signaling and activation of phosphodiesterase (PDE). Downstream effectors include the calcium/calmodulin-dependent kinase II (CaMK2) and PKC (reviewed in De, 2011). The WNT Ca2+ pathway is important in dorsoventral polarity, convergent extension and organ formation in vertebrates and also has roles in negatively regulating 'canonical' beta-catenin-dependent transcription. Non-canonical WNT Ca2+ signaling is also implicated in inflammatory response and cancer (reviewed in Kohn and Moon, 2005; Sugimura and Li, 2010).

Literature References
PubMed ID Title Journal Year
21181886 Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases Birth Defects Res. C Embryo Today 2010
16099039 Wnt and calcium signaling: beta-catenin-independent pathways Cell Calcium 2005
21903638 Wnt/Ca2+ signaling pathway: a brief overview Acta Biochim. Biophys. Sin. (Shanghai) 2011
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Orthologous Events