Reactome: A Curated Pathway Database

G alpha (q) signalling events

Stable Identifier
R-HSA-416476
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides a path to calcium-regulated kinases and phosphatases, GEFs, MAP kinase cassettes and other proteins that mediate cellular responses ranging from granule secretion, integrin activation, and aggregation in platelets. Gq participates in many other signalling events including direct interaction with RhoGEFs that stimulate RhoA activity and inhibition of PI3K. Both in vitro and in vivo, the G-protein Gq seems to be the predominant mediator of the activation of platelets.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database