Reactome: A Curated Pathway Database

G alpha (q) signalling events (R-HSA-416476) [Homo sapiens]


The classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides a path to calcium-regulated kinases and phosphatases, GEFs, MAP kinase cassettes and other proteins that mediate cellular responses ranging from granule secretion, integrin activation, and aggregation in platelets. Gq participates in many other signalling events including direct interaction with RhoGEFs that stimulate RhoA activity and inhibition of PI3K. Both in vitro and in vivo, the G-protein Gq seems to be the predominant mediator of the activation of platelets.

Additional Information
Compartment plasma membrane
Cross References
Database Identifier
BioModels Database BIOMD0000000088, BIOMD0000000081
Literature References
pubMedId Title Journal Year
19212139 Functions and regulatory mechanisms of Gq-signaling pathways Neurosignals 2009