Reactome: A Curated Pathway Database

Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity

Stable Identifier
R-HSA-416546
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Plexin-B1 functions as an R-Ras GTPase-activating protein (GAP) and directly and specifically down regulates R-Ras activity in response to Sema4D, inducing growth cone collapse. R-Ras inactivation promotes PI3K and Akt inactivation followed by GSK-3beta activation and CRMP inactivation. R-Ras inactivation also inhibits cell migration by regulating beta1 integrin activity.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
GTPase activator activity of Sema4D:pPlexin-B1:Met:Rnd1 [plasma membrane] Sema4D:pPlexin-B1:Met:Rnd1 [plasma membrane] GTPase activator activity (0005096)
Orthologous Events