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Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity

Stable Identifier
R-HSA-416546
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Plexin-B1 functions as an R-Ras GTPase-activating protein (GAP) and directly and specifically down regulates R-Ras activity in response to Sema4D, inducing growth cone collapse. R-Ras inactivation promotes PI3K and Akt inactivation followed by GSK-3beta activation and CRMP inactivation. R-Ras inactivation also inhibits cell migration by regulating beta1 integrin activity.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activator activity of SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane]
Physical Entity
Activity
Orthologous Events