Reactome: A Curated Pathway Database

Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (R-HSA-416546)

Species Homo sapiens


Plexin-B1 functions as an R-Ras GTPase-activating protein (GAP) and directly and specifically down regulates R-Ras activity in response to Sema4D, inducing growth cone collapse. R-Ras inactivation promotes PI3K and Akt inactivation followed by GSK-3beta activation and CRMP inactivation. R-Ras inactivation also inhibits cell migration by regulating beta1 integrin activity.

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Additional Information
Compartment cytosol , plasma membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
Sema4D:pPlexin-B1:Met:Rnd1 GTPase activator activity (0005096)