Reactome: A Curated Pathway Database

Sema4D mediated inhibition of cell attachment and migration

Stable Identifier
R-HSA-416550
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Repulsive Sema4D-Plexin-B1 signaling involves four GTPases, Rnd1, R-Ras, Rho and Rac1. Sema4D-Plexin-B1 binding promotes Rnd1-dependent activation of the plexin-B1 GAP domain and transient suppression of R-Ras activity. R-Ras inactivation promotes PI3K and Akt inactivation followed by GSK-3beta activation and CRMP2 inactivation. Plexin-B1 also transiently associates with and activates p190Rho-GAP, triggering a transient decrease in activated Rho.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events