Reactome: A Curated Pathway Database
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Sema4D induced cell migration and growth-cone collapse

Stable Identifier
R-HSA-416572
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Sema4D-mediated attraction of endothelial cells requires Rho, but not R-Ras, signaling. Sema4D-mediated plexinB1 activation activates Rho and its downstream effector ROCK. ROCK then phosphorylates MLC to induce actomyosin stress fiber contraction and to direct the assembly of focal adhesion complexes and integrin-mediated adhesion.

Literature References
Participants
Participant Of
Orthologous Events