Sema4D induced cell migration and growth-cone collapse (R-HSA-416572) [Homo sapiens]


Sema4D-mediated attraction of endothelial cells requires Rho, but not R-Ras, signaling. Sema4D-mediated plexinB1 activation activates Rho and its downstream effector ROCK. ROCK then phosphorylates MLC to induce actomyosin stress fiber contraction and to direct the assembly of focal adhesion complexes and integrin-mediated adhesion.

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane
Literature References
pubMedId Title Journal Year
12220504 Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors Biochem Biophys Res Commun 2002
15210733 Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2 J Cell Biol 2004
15818466 Plexins: axon guidance and signal transduction Cell Mol Life Sci 2005
18374575 Semaphorin signaling: progress made and promises ahead Trends Biochem Sci 2008
Inferred Entries
Orthologous events