Reactome: A Curated Pathway Database

G beta:gamma signalling through PLC beta (R-HSA-418217) [Homo sapiens]


Phospholipase C beta (PLCbeta) isoforms are activated by G-protein beta:gamma in the order PLCB3 > PLCB2 > PLCB1. Gbeta:gamma binds to the pleckstrin homology domain of PLC beta, increasing phospholipase activity and leading to increased hydrolysis of PIP2 to DAG and IP3.

Additional Information
Compartment cytoplasmic side of plasma membrane
Cross References
Database Identifier
BioModels Database BIOMD0000000088
Literature References
pubMedId Title Journal Year
8383116 Activation of phospholipase C isozymes by G protein beta gamma subunits J Biol Chem 1993