Reactome: A Curated Pathway Database
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G beta:gamma signalling through PLC beta

Stable Identifier
R-HSA-418217
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phospholipase C beta (PLCbeta) isoforms are activated by G-protein beta:gamma in the order PLCB3 > PLCB2 > PLCB1. Gbeta:gamma binds to the pleckstrin homology domain of PLC beta, increasing phospholipase activity and leading to increased hydrolysis of PIP2 to DAG and IP3.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database