Reactome: A Curated Pathway Database

G alpha (s) signalling events

Stable Identifier
R-HSA-418555
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated.

Literature References
Participants
Participant Of
Orthologous Events