Reactome: A Curated Pathway Database

G alpha (s) signalling events

Stable Identifier
R-HSA-418555
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase (Tesmer J J et al. 1997), which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated. Another downstream effector of G alpha (s) is the protein tyrosine kinase c-Src (Ma Y C et al. 2000).

Literature References
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Orthologous Events