Reactome: A Curated Pathway Database

G alpha (s) signalling events (R-HSA-418555)

Species Homo sapiens


The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated.

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Additional Information
Compartment plasma membrane