Reactome: A Curated Pathway Database

G alpha (s) signalling events (R-HSA-418555) [Homo sapiens]


The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated.

Additional Information
Compartment plasma membrane