Reactome: A Curated Pathway Database

G alpha (i) signalling events (R-HSA-418594)

Species Homo sapiens

Summation

The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases.

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane
Literature References
pubMedId Title Journal Year
9278091 Role of subunit diversity in signaling by heterotrimeric G proteins Biochem Pharmacol 1997
3113327 G proteins: transducers of receptor-generated signals Annu Rev Biochem 1987