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G alpha (z) signalling events
Stable Identifier
R-HSA-418597
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (z) signalling events (Homo sapiens)
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The heterotrimeric G protein G alpha (z), is a member of the G (i) family. Unlike other G alpha (i) family members it lacks an ADP ribosylation site cysteine four residues from the carboxyl terminus and is thus pertussis toxin-insensitive. It inhibits adenylyl cyclase types I, V and VI (Wong Y H et al. 1992). G alpha (z) interacts with the Rap1 GTPase activating protein (Rap1GAP) to attenuate Rap1 signaling. Like all G-proteins G alpha (z) has an intrinsic GTPase activity, but this activity tends to be lower for the pertussis toxin insensitive G-proteins, most strikingly so for G alpha (z), whose kcat value for GTP hydrolysis is 200-fold lower than those of G alpha (s) or G alpha (i) (Grazziano et al. 1989). G alpha (z) knockout mice have disrupted platelet aggregation at physiological concentrations of epinephrine and responses to several neuroactive drugs are altered (Yang et al. 2000). Regulator of G-protein Signalling (RGS) proteins can regulate the activity of G alpha (z) (Soundararajan M et al. 2008).
Literature References
PubMed ID
Title
Journal
Year
1908722
Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes
Manning, DR
,
Poncz, M
,
Gagnon, AW
,
Brass, LF
,
Gewirtz, A
,
Catani, L
Blood
1991
11313909
G(z) signaling: emerging divergence from G(i) signaling
Ho, MK
,
Wong, YH
Oncogene
2001
Participants
Events
Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz
(Homo sapiens)
Liganded Gz-activating GPCR acts as a GEF for Gz
(Homo sapiens)
The Ligand:GPCR:Gz complex dissociates
(Homo sapiens)
G alpha (z) inhibits adenylate cyclase
(Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
(Homo sapiens)
PKC phosphorylates G alpha (z)
(Homo sapiens)
G alpha (z) auto-inactivates by hydrolysing GTP to GDP
(Homo sapiens)
Inactive G alpha (z) reassociates with G beta:gamma
(Homo sapiens)
Active G alpha (z) binds RGS proteins
(Homo sapiens)
G alpha (z) in G alpha (z):RGS complex is inactivated
(Homo sapiens)
G alpha (z):RGS complex dissociates to give inactive G alpha (z)
(Homo sapiens)
PKC binds active G alpha (z)
(Homo sapiens)
G-alpha(z):PKC dissociates to give phosphorylated G alpha (z)
(Homo sapiens)
Participates
as an event of
GPCR downstream signalling (Homo sapiens)
Orthologous Events
G alpha (z) signalling events (Bos taurus)
G alpha (z) signalling events (Caenorhabditis elegans)
G alpha (z) signalling events (Canis familiaris)
G alpha (z) signalling events (Dictyostelium discoideum)
G alpha (z) signalling events (Drosophila melanogaster)
G alpha (z) signalling events (Gallus gallus)
G alpha (z) signalling events (Mus musculus)
G alpha (z) signalling events (Rattus norvegicus)
G alpha (z) signalling events (Saccharomyces cerevisiae)
G alpha (z) signalling events (Schizosaccharomyces pombe)
G alpha (z) signalling events (Sus scrofa)
G alpha (z) signalling events (Xenopus tropicalis)
Authored
Jupe, S (2009-04-24)
Reviewed
Akkerman, JW (2009-06-03)
Created
Jupe, S (2009-04-24)
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