Reactome: A Curated Pathway Database

DCC mediated attractive signaling

Stable Identifier
R-HSA-418885
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The DCC family includes DCC and neogenin in vertebrates. DCC is required for netrin-induced axon attraction. DCC is a transmembrane protein lacking any identifiable catalytic activity. Protein tyrosine kinase 2/FAK and src family kinases bind constitutively to the cytoplasmic domain of DCC and their activation couples to downstream intracellular signaling complex that directs the organization of actin.

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database