Reactome: A Curated Pathway Database

Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex (R-HSA-419534)

Species Homo sapiens

Summation

Lysine 561 of FANCD2 is monoubiquitinated by FANCL, a component of the FA core complex with ubiquitin ligase activity (Garcia Higuera et al., 2001). UBE2T binds to FANCL, and is required for the monoubiquitination of FANCD2 (Machida et al., 2006). Monoubiquitination of FANCD2 in turn is necessary for its localization to chromatin and for the formation of nuclear foci in response to DNA damage. FANCD2 ubiquitination requires the presence of FANCI although the molecular role of FANCI in FANCD2 ubiquitination is unknown.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Catalyst Activity
PhysicalEntity Activity Active Units
FA core complex ubiquitin-protein transferase activity (0004842)
This entry is regulated by
Regulation type Name
Requirement