Reactome: A Curated Pathway Database

Monoubiquitination of FANCI by the FA ubiquitin ligase complex (R-HSA-419539)

Species Homo sapiens


FANCI is monoubiquitinated on lysine 523 in an FA core-complex-dependent manner (Sims et al., 2007; Smogorzewska et al. 2007). FANCD2 and FANCI are mutually dependent on each other for their respective monoubiquitination. However, multiple phosphorylation of FANCI but not monoubiquitination is crucial for FANCD2 activation following DNA damage (Ishiai et al., 2008).

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Catalyst Activity
PhysicalEntity Activity Active Units
FA core complex ubiquitin-protein transferase activity (0004842)
This entry is regulated by
Regulation type Name