The class C G-protein-coupled receptors are a class of G-protein coupled receptors that include the metabotropic glutamate receptors and several additional receptors (Brauner-Osborne H et al, 2007). Family C GPCRs have a large extracellular N-terminus which binds the orthosteric (endogenous) ligand. The shape of this domain is often likened to a clam. Several allosteric ligands to these receptors have been identified and these bind within the seven transmembrane region.
|12782243||Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors||Pharmacol Ther||2003|
|17266540||Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors||Curr Drug Targets||2007|