Reactome: A Curated Pathway Database

Class C/3 (Metabotropic glutamate/pheromone receptors)

Stable Identifier
R-HSA-420499
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The class C G-protein-coupled receptors are a class of G-protein coupled receptors that include the metabotropic glutamate receptors and several additional receptors (Brauner-Osborne H et al, 2007). Family C GPCRs have a large extracellular N-terminus which binds the orthosteric (endogenous) ligand. The shape of this domain is often likened to a clam. Several allosteric ligands to these receptors have been identified and these bind within the seven transmembrane region.

Literature References
Participants
Participant Of
Orthologous Events