Phosphorylation of FANCI by ATM/ATR
Species Homo sapiens
FANCI phosphorylation may function as a molecular switch to turn on the
Fanconi anemia pathway in response to DNA damage or replication fork stress (Ishiai et al., 2008). Multiple phosphorylation sites within FANCI are functionally important for inducing monoubiquitination of FANCD2. Several lines of evidence support the notion that the ATR kinase is involved in this phosphorylation (Ishiai et al., 2008).
Locations in the PathwayBrowser
DNA Repair(Homo sapiens)