Reactome: A Curated Pathway Database

Phosphorylation of FANCI by ATM/ATR (R-HSA-420769)

Species Homo sapiens

Summation

FANCI phosphorylation may function as a molecular switch to turn on the Fanconi anemia pathway in response to DNA damage or replication fork stress (Ishiai et al., 2008). Multiple phosphorylation sites within FANCI are functionally important for inducing monoubiquitination of FANCD2. Several lines of evidence support the notion that the ATR kinase is involved in this phosphorylation (Ishiai et al., 2008).

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
ATM/ATR kinase protein serine/threonine kinase activity (0004674)
Literature References
pubMedId Title Journal Year
18931676 FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway Nat Struct Mol Biol 2008