Reactome: A Curated Pathway Database

Phosphorylation of FANCD2 by ATR/ATM (R-HSA-420770)

Species Homo sapiens

Summation

ATR and ATM dependent phosphorylation of FANCD2 promotes the monoubiquitination of FANCD2 stimulating the FA pathway (Andreassen et al., 2004; Ho et al., 2006).

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
ATM/ATR kinase protein serine/threonine kinase activity (0004674)
Literature References
pubMedId Title Journal Year
16943440 Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance Mol Cell Biol 2006