Reactome: A Curated Pathway Database

Cell-cell junction organization (R-HSA-421270)

Species Homo sapiens

Summation

Epithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and composition. AJs play a critical role in initiating cell-cell contacts and promoting the maturation and maintenance of the contacts (reviewed in Ebnet, 2008; Hartsock and Nelson, 2008). TJs form physical barriers in various tissues and regulate paracellular transport of water, ions, and small water soluble molecules (reviewed in Rudini and Dejana, 2008; Ebnet, 2008; Aijaz et al., 2006; Furuse and Tsukit, 2006). Desmosomes mediate strong cell adhesion linking the intermediate filament cytoskeletons between cells and playing roles in wound repair, tissue morphogenesis, and cell signaling (reviewed in Holthofer et al., 2007).

Locations in the PathwayBrowser
Additional Information
GO Biological Process cell-cell junction organization (0045216)
Literature References
pubMedId Title Journal Year
16487793 Tight junctions: molecular architecture and function Int Rev Cytol 2006
19081036 Adherens junctions Curr Biol 2008
17854762 Adherens and tight junctions: structure, function and connections to the actin cytoskeleton Biochim Biophys Acta 2008
1616050 Structure, function, and regulation of cellular tight junctions Am J Physiol 1992
16537104 Claudins in occluding junctions of humans and flies Trends Cell Biol 2006