Reactome: A Curated Pathway Database

trans-Golgi Network Coat Assembly (R-HSA-421831) [Homo sapiens]


Once the basic components of the docking complex are assembled with one end of AP-1 bound to cargo molecules, the other end binds to clathrin. Clathrin triskelions polymerize into hexagons and pentagons, forming a cage, which leads to membrane deformation. This polymerization step drives the sculpting of the vesicle. The number of clathrin triskelions required to sculpt a vesicle appears to be variable, but has been estimated to require 36 - 60 triskelions assocaited with 30 - 66 AP-1 complexes. Here a ~380 angstroms vesicle is represented with 48 clathrin triskelions and 52 AP-1 complexes.

Additional Information
Compartment Golgi membrane , cytosol
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Literature References
pubMedId Title Journal Year
10394364 Functional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography Mol Cell 1999
11994746 Regulated transport of the glucose transporter GLUT4. Nat Rev Mol Cell Biol 2002