Reactome: A Curated Pathway Database

Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (R-HSA-421833) [Homo sapiens]


Once AP-1 is recruited to the trans-Golgi Network membrane the complex of functional vesicle building proteins is joined by the cargo that will be within that vesicle. As with other types of vesicles the cargo itself is part of the vesicle development. Here the cargo is destined for the Golgi-associated vesicle membrane. It is at this stage that a specific Synaptobrevin (Vamp) molecule also joins the complex. It should be noted that only certain Vamp molecules will be found with specific cargo molecules on the newly forming vesicles. However here we represent this reaction in bulk, without specific Vamp and cargo molecule pairings.

Additional Information
Compartment cytosol
Literature References
pubMedId Title Journal Year
11694590 GGAs: roles of the different domains and comparison with AP-1 and clathrin Mol Biol Cell 2001
11994746 Regulated transport of the glucose transporter GLUT4. Nat Rev Mol Cell Biol 2002
17116749 Comparative proteomics of clathrin-coated vesicles J Cell Biol 2006