Reactome: A Curated Pathway Database

Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture

Stable Identifier
R-HSA-421833
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Once AP-1 is recruited to the trans-Golgi Network membrane the complex of functional vesicle building proteins is joined by the cargo that will be within that vesicle. As with other types of vesicles the cargo itself is part of the vesicle development. Here the cargo is destined for the Golgi-associated vesicle membrane. It is at this stage that a specific Synaptobrevin (Vamp) molecule also joins the complex. It should be noted that only certain Vamp molecules will be found with specific cargo molecules on the newly forming vesicles. However here we represent this reaction in bulk, without specific Vamp and cargo molecule pairings.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events