Reactome: A Curated Pathway Database

trans-Golgi Network Vesicle Scission (R-HSA-421835) [Homo sapiens]


Dynamin is recruited to the growing vesicle and, under conditions that interfere with its GTPase activity, dynamin forms a collar or ring around the neck of the budding vesicle. It is unclear whether dynamin acts as a mechanochemical transducer to generate fission or as a recruiter to attach other proteins that are directly responsible for the fission step. Lipid-modifying enzymes such as endophilin are also involved in vesicle formation. Endophilin is an acyltransferase that interacts with dynamin and that generates lysophosphatidic acid. The current view is that this reaction produces a negative curvature at the neck of the vesicle.

Additional Information
Compartment cytosol
Literature References
pubMedId Title Journal Year
8670264 Dynamin II binds to the trans-Golgi network Biochem Biophys Res Commun 1996
11604418 Generation of high curvature membranes mediated by direct endophilin bilayer interactions J Cell Biol 2001
11994746 Regulated transport of the glucose transporter GLUT4. Nat Rev Mol Cell Biol 2002