Reactome: A Curated Pathway Database
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Clathrin derived vesicle budding

Stable Identifier
R-HSA-421837
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

There at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the clathrin-coated vesicles emerging from the Golgi apparatus are triggered by the heterotetrameric adaptor protein complex, AP-1 at the trans-Golgi network membrane. The cargo can be transmembrane, membrane associated or golgi luminal proteins. Each step in the vesicle sculpting pathway, gathers cargo and clathrin triskeletons, until a complete vesicular sphere is formed. With the scission of the membrane the vesicle is released and eventually losses its clathrin coat.

Participants
Participant Of
Orthologous Events