Reactome: A Curated Pathway Database

Butyrylcholinesterase and Platelet-activating factor acetylhydrolase hydrolyze acyl Ghrelin

Stable Identifier
R-HSA-422058
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Deacylation of acyl Ghrelin
Locations in the PathwayBrowser
Summation

The majority of circulating ghrelin is not acylated (des-acyl ghrelin). Acyl ghrelin can be deacylated in the bloodstream by butyrylcholinesterase and platelet-activating factor acetylhydrolase, which are associated with circulating lipids. Other enzymes may also have this capability. It is unknown if a portion of des-acyl ghrelin in the bloodstream is generated by direct synthesis and secretion.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
hydrolase activity, acting on ester bonds of Butyrylcholinesterase [extracellular region] Butyrylcholinesterase [extracellular region] hydrolase activity, acting on ester bonds (0016788)
hydrolase activity, acting on ester bonds of PLA2G7 [extracellular region] PLA2G7 [extracellular region] hydrolase activity, acting on ester bonds (0016788)
Orthologous Events