Reactome: A Curated Pathway Database

Butyrylcholinesterase and Platelet-activating factor acetylhydrolase hydrolyze acyl Ghrelin (R-HSA-422058) [Homo sapiens]

Black Box Event

The majority of circulating ghrelin is not acylated (des-acyl ghrelin). Acyl ghrelin can be deacylated in the bloodstream by butyrylcholinesterase and platelet-activating factor acetylhydrolase, which are associated with circulating lipids. Other enzymes may also have this capability. It is unknown if a portion of des-acyl ghrelin in the bloodstream is generated by direct synthesis and secretion.

Additional Information
Compartment extracellular region
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Literature References
pubMedId Title Journal Year
15256494 Ghrelin degradation by serum and tissue homogenates: identification of the cleavage sites Endocrinology 2004
17289852 Ghrelin interacts with human plasma lipoproteins Endocrinology 2007
19280057 Ghrelin fluctuation, what determines its production? Acta Biochim Biophys Sin (Shanghai) 2009
18396350 Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle Peptides 2008