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Butyrylcholinesterase and Platelet-activating factor acetylhydrolase hydrolyze acyl Ghrelin

Stable Identifier
R-HSA-422058
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Synonyms
Deacylation of acyl Ghrelin
Locations in the PathwayBrowser
Summation

The majority of circulating ghrelin is not acylated (des-acyl ghrelin). Acyl ghrelin can be deacylated in the bloodstream by butyrylcholinesterase and platelet-activating factor acetylhydrolase, which are associated with circulating lipids. Other enzymes may also have this capability. It is unknown if a portion of des-acyl ghrelin in the bloodstream is generated by direct synthesis and secretion.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
hydrolase activity, acting on ester bonds of PLA2G7 [extracellular region]
Physical Entity
Activity
Title
hydrolase activity, acting on ester bonds of Butyrylcholinesterase [extracellular region]
Physical Entity
Activity
Orthologous Events