The majority of circulating ghrelin is not acylated (des-acyl ghrelin). Acyl ghrelin can be deacylated in the bloodstream by butyrylcholinesterase and platelet-activating factor acetylhydrolase, which are associated with circulating lipids. Other enzymes may also have this capability. It is unknown if a portion of des-acyl ghrelin in the bloodstream is generated by direct synthesis and secretion.
|Butyrylcholinesterase||hydrolase activity, acting on ester bonds (0016788)|
|PLA2G7||hydrolase activity, acting on ester bonds (0016788)|
|15256494||Ghrelin degradation by serum and tissue homogenates: identification of the cleavage sites||Endocrinology||2004|
|17289852||Ghrelin interacts with human plasma lipoproteins||Endocrinology||2007|
|19280057||Ghrelin fluctuation, what determines its production?||Acta Biochim Biophys Sin (Shanghai)||2009|
|18396350||Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle||Peptides||2008|