Reactome: A Curated Pathway Database

Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (R-HSA-425366)

Species Homo sapiens


Hexoses like glucose, galactose and fructose serve as basic fuel molecules for eukaryotic cells. Indeed, glucose is the main energy source for mammalian cells. These sugars are unable to diffuse across cellular membranes, and require transporter proteins for entry into and exit out of cells. Four gene families encode hexose transporter proteins (He et al, 2009). SLC2 family contains 14 genes and encode facilitative glucose transporters (GLUTs) (Uldry M and Thorens B, 2004). SLC5 family contains 12 genes and encode Na+/glucose symporters (Wright EM and Turk E, 2004). SLC37 family contains 4 members and encode sugar-phosphate/phosphate exchangers (Bartoloni L and Antonarakis SE, 2004). SLC45 family has 4 members and encode putative sugar/H+ symporters.

Locations in the PathwayBrowser
Literature References
pubMedId Title Journal Year
19164095 Analysis and update of the human solute carrier (SLC) gene superfamily Hum Genomics 2009
12750891 The SLC2 family of facilitated hexose and polyol transporters Pflugers Arch 2004
12748858 The sodium/glucose cotransport family SLC5 Pflugers Arch 2004
12811562 The human sugar-phosphate/phosphate exchanger family SLC37 Pflugers Arch 2004
Inferred Entries
Orthologous events