Sodium/Proton exchangers

Stable Identifier
R-HSA-425986
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The SLC9 gene family encode proteins (sodium/proton exchangers, NHE or NHX) which exchange sodium (influx) for protons (efflux) electroneutrally. This mechanism is important because many metabolic processes generate acids which need to be removed to maintain pH. This is the major proton extruding system in cells, driven by the inward sodium ion chemical gradient. To date, there are eleven NHE genes, NHE1-11. NHE1-5 exchange cations at the cell membrane. NHE6-9 exchange cations at endosomal membranes or the trans-golgi network membranes.

Literature References
PubMed ID Title Journal Year
12845533 Diversity of the mammalian sodium/proton exchanger SLC9 gene family

Orlowski, J, Grinstein, S

Pflugers Arch 2004
11279194 Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network

Numata, M, Orlowski, J

J Biol Chem 2001
15522866 Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation

Nakamura, N, Tanaka, S, Teko, Y, Mitsui, K, Kanazawa, H

J Biol Chem 2005
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