Reactome: A Curated Pathway Database

Sodium/Proton exchangers

Stable Identifier
R-HSA-425986
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The SLC9 gene family encode proteins (sodium/proton exchangers, NHE or NHX) which exchange sodium (influx) for protons (efflux) electroneutrally. This mechanism is important because many metabolic processes generate acids which need to be removed to maintain pH. This is the major proton extruding system in cells, driven by the inward sodium ion chemical gradient. To date, there are eleven NHE genes, NHE1-11. NHE1-5 exchange cations at the cell membrane. NHE6-9 exchange cations at endosomal membranes or the trans-golgi network membranes.

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database