Reactome | TRPC3(1-848) [plasma membrane]

TRPC3(1-848) [plasma membrane]

Stable Identifier

R-HSA-426172

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

TRPC3, Transient receptor potential channel 3, Short transient receptor potential channel 3, TRPC3_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13507 TRPC3

Gene Names

TRPC3, TRP3

Chain

chain:1-921

Reference Genes

BioGPS Gene:7222 TRPC3

COSMIC (genes):TRPC3 TRPC3

CTD Gene:7222 TRPC3

dbSNP Gene:7222 TRPC3

ENSEMBL:ENSG00000138741 TRPC3

ENSEMBL_homo_sapiens_GENE:ENSG00000138741.11 TRPC3

HGNC:12335 TRPC3

KEGG Gene (Homo sapiens):7222 TRPC3

Monarch:7222 TRPC3

NCBI Gene:7222 TRPC3

OMIM:602345 TRPC3

UCSC:Q13507 TRPC3

Reference Transcript

Other Identifiers

11737164_s_at

11756921_a_at

16979553

206425_PM_s_at

206425_s_at

210814_PM_at

210814_at

2784166

2784167

2784168

2784169

2784170

2784172

2784174

2784176

2784178

2784179

2784180

2784181

2784183

2784184

2784185

2784187

2784188

2784189

2784190

2784191

2784192

2784197

2784198

2784199

2784200

2784201

2784205

2784206

2784207

2784208

2784209

2784210

2784211

2784212

34984_at

7222

8102678

A_23_P41455

GE893834

GO:0003012

GO:0005215

GO:0005216

GO:0005227

GO:0005262

GO:0005515

GO:0005886

GO:0006811

GO:0006816

GO:0007338

GO:0007602

GO:0010524

GO:0015279

GO:0016020

GO:0022414

GO:0023052

GO:0033198

GO:0034220

GO:0034703

GO:0046872

GO:0051480

GO:0051592

GO:0055065

GO:0055085

GO:0070588

GO:0070679

GO:1903244

HMNXSV003006511

HMNXSV003036956

ILMN_2094377

PH_hs_0027880

TC04001518.hg

TC04002702.hg

U47050_at

g4507686_3p_a_at

Participates

as a member of

as an output of

TRPC3 gene transcription is stimulated by MECP2 (Homo sapiens)

Inferred To

TRPC3(1-848) [plasma membrane] (Gallus gallus)

TRPC3(1-848) [plasma membrane] (Mus musculus)

TRPC3(1-848) [plasma membrane] (Rattus norvegicus)

trpc3 [plasma membrane] (Xenopus tropicalis)

TRPC3 [plasma membrane] (Bos taurus)

TRPC3 [plasma membrane] (Canis familiaris)

TRPC3 [plasma membrane] (Sus scrofa)

trp-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001124170.1, NP_003296.1

Guide to Pharmacology - Targets

488

OpenTargets

ENSG00000138741

ZINC - Substances

TRPC3_HUMAN

ZINC target

Q13507

PRO

Q13507

PDB

6D7L, 6CUD, 7DXC, 7DXE, 6DJS, 7DXB, 7DXD, 5ZBG

GeneCards

Q13507

HPA

ENSG00000138741-TRPC3

Ensembl

ENSP00000368966, ENST00000264811, ENSG00000138741, ENST00000379645, ENSP00000264811

Pharos - Targets

Q13507

Orphanet

23836

ZINC - Predictions - Purchasable

TRPC3_HUMAN

HMDB Protein

HMDBP02622

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14573 ITPR3	2	ITPR3 [platelet dense tubular network membrane] (R-HSA-418283) ITPR3 [endoplasmic reticulum membrane] (R-HSA-169690)	0.591	5
UniProt:Q96D31 ORAI1	1	ORAI1 [plasma membrane] (R-HSA-434672)	0.544	2
UniProt:P20591 MX1	1	MX1 [cytosol] (R-HSA-947489)	0.524	2
UniProt:P10686 Plcg1	8	p-4Y-Plcg1 [plasma membrane] (R-RNO-9034825) phospho-p-Y771,Y783-PLCG1 [plasma membrane] (R-RNO-1169084) phospho-p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-RNO-202357) PLCG1 [cytosol] (R-RNO-202320) p-Plcg1 [plasma membrane] (R-RNO-182042) Plcg1 [plasma membrane] (R-RNO-182093) PLCG1 [plasma membrane] (R-RNO-167682) phospho-p-4Y-PLCG1 [plasma membrane] (R-RNO-167679)	0.508	2