Reactome: A Curated Pathway Database

Multifunctional anion exchangers (R-HSA-427601)

Species Homo sapiens


The human SLC26 gene family consists of eleven members which encode multifunctional anion exchangers.These exchangers are capable of transporting a variety of anions such as sulphate, bicarbonate, oxalate, hydroxyl, formate, iodide and chloride. SLC26 members can be grouped according to functional similiarities and three groups can be classified this way. Group 1 are selective sulphate transporters and include SLC26A1 and 2. Group 2 are Cl-/HCO3- exchangers and include SLC26A3, 4 and 6. Group 3 function as ion channels and include SLC26A7 and 9.

Locations in the PathwayBrowser
Literature References
pubMedId Title Journal Year
18400693 The solute carrier 26 family of proteins in epithelial ion transport Physiology (Bethesda) 2008
12759755 The SLC26 gene family of multifunctional anion exchangers Pflugers Arch 2004