Reactome: A Curated Pathway Database

SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol

Stable Identifier
R-HSA-427605
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Type III Na+/Pi cotransport
Locations in the PathwayBrowser
Summation

There are two transporters of this type; The genes SLC20A1 and SLC20A2 encode for phosphate transporters 1 and 2 (PiT1 and PiT2 respectively). They both have a broad tissue distribution and may play a general housekeeping role in phosphate transport such as absorbing phosphate from interstitial fluid and in extracellular matrix and cartilage calcification as well as in vascular calcification. These proteins were originally described as retroviral receptors for the gibbin ape leukemia virus receptor 1 (GLVR1, now called PiT1) (O'Hara et al. 1990) and GLVR2 (now called PiT2) (van Zeijl et al.1994). However, they were found to possess Na+-coupled phosphate cotransporter function (Fernandes et al. 1999). The transport is electrogenic with a stoichiometry of 2:1 (Na+:Pi).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
sodium-dependent phosphate transmembrane transporter activity of Type III Na+/Pi cotransporters [plasma membrane] Type III Na+/Pi cotransporters [plasma membrane] sodium-dependent phosphate transmembrane transporter activity (0015321)
Orthologous Events