Phosphorus is an essential element that is critical for structural and metabolic roles in all living organisms. Cells obtain phosphorus in the form of negatively-charged inorganic phosphate (Pi). Two SLC families transport phosphate in mammals; SLC34 (Murer H et al, 2004) and SLC20 (Collins JF et al, 2004). Both are secondary-active, Na+-coupled transporter systems which use the inward Na+ gradient (from the Na+-K+-ATPase) to drive phosphate influx into cells (Virkki LV et al, 2007).
|17581921||Phosphate transporters: a tale of two solute carrier families||Am J Physiol Renal Physiol||2007|
|12750889||The sodium phosphate cotransporter family SLC34||Pflugers Arch||2004|
|12759754||The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors||Pflugers Arch||2004|