Reactome: A Curated Pathway Database

Sodium-coupled phosphate cotransporters (R-HSA-427652) [Homo sapiens]


Phosphorus is an essential element that is critical for structural and metabolic roles in all living organisms. Cells obtain phosphorus in the form of negatively-charged inorganic phosphate (Pi). Two SLC families transport phosphate in mammals; SLC34 (Murer H et al, 2004) and SLC20 (Collins JF et al, 2004). Both are secondary-active, Na+-coupled transporter systems which use the inward Na+ gradient (from the Na+-K+-ATPase) to drive phosphate influx into cells (Virkki LV et al, 2007).

Cross References
Database Identifier
BioModels Database BIOMD0000000054
Literature References
pubMedId Title Journal Year
17581921 Phosphate transporters: a tale of two solute carrier families Am J Physiol Renal Physiol 2007
12750889 The sodium phosphate cotransporter family SLC34 Pflugers Arch 2004
12759754 The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors Pflugers Arch 2004