Reactome: A Curated Pathway Database

Recruitment of Profilin by Ena/Vasp proteins (R-HSA-428534) [Homo sapiens]


Ena/VASP proteins enhance actin filament elongation via the recruitment of profilin:actin complexes to the tips of spreading lamellipodia. Profilin binds to the central proline rich domain of Ena/VASP protein.

Additional Information
Compartment cytosol , plasma membrane
Literature References
pubMedId Title Journal Year
10892742 Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor Cell 2000