Reactome: A Curated Pathway Database

Inactivation of Cdc42 and Rac

Stable Identifier
R-HSA-428543
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Rho family GTPases including Rac, Rho, and Cdc42 are ideal candidates to regulate aspects of cytoskeletal dynamics downstream of axon guidance receptors. Biochemical and genetic studies have revealed an important role for Cdc42 and Rac in Robo repulsion. Robo controls the activity of Rho GTPases by interacting with a family of Slit/Robo specific GAPs (SrGAPs) and Vilse/CrossGAP. SrGAPs inactivate Cdc42 and Vilse/CrossGAP specifically inactivates Rac1.

Participants
Participant Of
Orthologous Events