Reactome: A Curated Pathway Database

Thromboxane signalling through TP receptor (R-HSA-428930) [Homo sapiens]


Thromboxane (TXA2) binds to the thromboxane receptor (TP). There are 2 splice variant forms of TP, differing in their cytoplasmic carboxyl terminal tails. TP beta was first identified in endothelial cells. TP alpha was identified in platelets and placenta. The major signalling route for TP is Gq-mediated stimulation of PLC and consequent increase in cellular calcium. TP also couples to G13, leading to stimulation of Rho and Rac.

Additional Information
Compartment plasma membrane
Cross References
Database Identifier
BioModels Database BIOMD0000000088
Literature References
pubMedId Title Journal Year
18374420 Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology Pharmacol Ther 2008