Reactome: A Curated Pathway Database

CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER] (R-HSA-429683) [Homo sapiens]

Reaction
Summation

â??CERTâ?? (ceramide transfer protein), associated with the cytosolic face of the endoplasmic reticulum (ER) in a complex with VAPA or VAPB (VAMP-associated proteins A or B) (Kawano et al. 2006) and PPM1L (protein phosphatase 1-like) (Saito et al. 2008), can bridge the gap between the ER and the Golgi apparatus via its PH domain and transfer a molecule of ceramide extracted from the ER membrane to the Golgi (Hanada et al. 2003; Saito et al. 2008). â??CERTâ??-mediated ceramide transfer is positively regulated by OSBP (oxysterol binding protein), by an unknown mechanism (Perry and Ridgway 2006).

Additional Information
Compartment endoplasmic reticulum membrane
This entry is regulated by
Regulation type Name
PositiveRegulation