Reactome: A Curated Pathway Database
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CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER]

Stable Identifier
R-HSA-429683
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
â??CERTâ?? protein releases its bound ceramide into the membrane of the Golgi apparatus
Locations in the PathwayBrowser
Summation

â??CERTâ?? (ceramide transfer protein), associated with the cytosolic face of the endoplasmic reticulum (ER) in a complex with VAPA or VAPB (VAMP-associated proteins A or B) (Kawano et al. 2006) and PPM1L (protein phosphatase 1-like) (Saito et al. 2008), can bridge the gap between the ER and the Golgi apparatus via its PH domain and transfer a molecule of ceramide extracted from the ER membrane to the Golgi (Hanada et al. 2003; Saito et al. 2008). â??CERTâ??-mediated ceramide transfer is positively regulated by OSBP (oxysterol binding protein), by an unknown mechanism (Perry and Ridgway 2006).

Literature References
Participants
Participant Of
This entity is regulated by:
Orthologous Events