Reactome: A Curated Pathway Database

NCK recruits WASP (R-HSA-430180) [Homo sapiens]


The second SH3 domain of NCK interacts with the carboxy-terminal SH3 domain of WASP. WASP family proteins bind the Arp2/3 complex, stimulating its ability to nucleate actin filaments and induce filament branching.

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Literature References
pubMedId Title Journal Year
7565724 Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains Mol Cell Biol 1995