Reactome: A Curated Pathway Database

Vasopressin regulates renal water homeostasis via Aquaporins (R-HSA-432040)

Species Homo sapiens

Summation

In the kidney water and solutes are passed out of the bloodstream and into the proximal tubule via the slit-like structure formed by nephrin in the glomerulus. Water is reabsorbed from the filtrate during its transit through the proximal tubule, the descending loop of Henle, the distal convoluted tubule, and the collecting duct.
Aquaporin-1 (AQP1) in the proximal tubule and the descending thin limb of Henle is responsible for about 90% of reabsorption (as estimated from mouse knockouts of AQP1). AQP1 is located on both the apical and basolateral surface of epithelial cells and thus transports water through the epithelium and back into the bloodstream.
In the collecting duct epithelial cells have AQP2 on their apical surface and AQP3 and AQP4 on their basolateral surface to transport water across the epithelium. The permeability of the epithelium is regulated by vasopressin, which activates the phosphorylation and subsequent translocation of AQP2 from intracellular vesicles to the plasma membrane.

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane
GO Biological Process renal water homeostasis (0003091)
Literature References
pubMedId Title Journal Year
15924268 The renal plumbing system: aquaporin water channels Cell Mol Life Sci 2005
17222168 Regulation and dysregulation of aquaporins in water balance disorders J Intern Med 2007
11773613 Aquaporins in the kidney: from molecules to medicine Physiol Rev 2002
19096775 Regulation of aquaporin-2 trafficking Handb Exp Pharmacol 2009
18566824 Localization and trafficking of aquaporin 2 in the kidney Histochem Cell Biol 2008