Reactome: A Curated Pathway Database

Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (R-HSA-432110)

Species Homo sapiens

Summation

The binding of SHC to integrin alpha IIb beta 3 is blocked by phosphorylation of beta 3 at Thr-779, or by substitution of this residue for Asp. PDK1 and Akt1/PKB-alpha both specifically target Thr-779 in in vitro assays.

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
AKT1/PDK1 protein serine/threonine kinase activity (0004674)