Reactome: A Curated Pathway Database

Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding

Stable Identifier
R-HSA-432110
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The binding of SHC to integrin alpha IIb beta 3 is blocked by phosphorylation of beta 3 at Thr-779, or by substitution of this residue for Asp. PDK1 and Akt1/PKB-alpha both specifically target Thr-779 in in vitro assays.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of AKT1/PDK1 [plasma membrane] AKT1/PDK1 [plasma membrane] protein serine/threonine kinase activity (0004674)
Orthologous Events