Reactome: A Curated Pathway Database

Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (R-HSA-432110) [Homo sapiens]


The binding of SHC to integrin alpha IIb beta 3 is blocked by phosphorylation of beta 3 at Thr-779, or by substitution of this residue for Asp. PDK1 and Akt1/PKB-alpha both specifically target Thr-779 in in vitro assays.

Additional Information
Compartment plasma membrane
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Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
AKT1/PDK1 protein serine/threonine kinase activity (0004674)