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Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding

Stable Identifier
R-HSA-432110
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The binding of SHC to integrin alpha IIb beta 3 is blocked by phosphorylation of beta 3 at Thr-779, or by substitution of this residue for Asp. PDK1 and Akt1/PKB-alpha both specifically target Thr-779 in in vitro assays.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of AKT1/PDK1 [plasma membrane]
Physical Entity
Activity
Orthologous Events