Reactome: A Curated Pathway Database

Unblocking of NMDA receptor

Stable Identifier
R-HSA-432162
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NMDA receptors are activated in a two step mechanism; first by the removal of the voltage dependent Mg2+ block and then by the ligand dependent activation of the unblocked NMDA receptor. At resting membrane potential NMDA receptors can not be activated by ligand alone due to the presence of Mg2+ ion in the pore of the channel. Due to the activation of other membrane resident channels that allow the influx of Na+ the membrane is depolarized which triggers the removal of Mg2+ form the NMDA receptor pore. Once the Mg2+ is expelled NMDA receptors are ready to be activated by the agonist (glutamate) and the co-agonist (glycine).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
excitatory extracellular ligand-gated ion channel activity of Ca impermeable AMPA receptors [plasma membrane] Ca impermeable AMPA receptors [plasma membrane] excitatory extracellular ligand-gated ion channel activity (0005231)
Orthologous Events