Reactome: A Curated Pathway Database

Activation of NMDA Receptor (R-HSA-432164)

Species Homo sapiens


NMDA receptors are activated upon binding of two ligands, glutamate and glycine.
The activation leads to Ca2+ influx into the post-synaptic cell. The local rise in the Ca2+ ion concentration further leads to activation of several Ca2+ dependent pathways leading to long term changes in the synapse.

Locations in the PathwayBrowser
Additional Information
Compartment extracellular region , plasma membrane , cytosol