Reactome: A Curated Pathway Database

Ca2+ influx into the post-synaptic cell

Stable Identifier
R-HSA-432164
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NMDA receptors are activated upon binding of two ligands, glutamate and glycine.
The activation leads to Ca2+ influx into the post-synaptic cell. The local rise in the Ca2+ ion concentration further leads to activation of several Ca2+ dependent pathways leading to long term changes in the synapse.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
excitatory extracellular ligand-gated ion channel activity of NMDA receptor ligand complex [plasma membrane] NMDA receptor ligand complex [plasma membrane] excitatory extracellular ligand-gated ion channel activity (0005231)
Orthologous Events