Reactome: A Curated Pathway Database

Activation of NMDA receptor (R-HSA-432172) [Homo sapiens]

Reaction
Summation

NMDA receptors require binding of two ligands; the agonist, glutamate and co-agonist, glycine. The N terminal extracellular ligand binding domain in NR1 subunits binds co-agonist glycine and the N terminal extracellular ligand binding domain in NR2 binds glutamate.

Additional Information
Compartment extracellular region , plasma membrane , cytosol
Literature References
pubMedId Title Journal Year
8665664 Developmental rearrangements of cortical glutamate-NMDA receptor binding sites in late human gestation Brain Res Dev Brain Res 1995