Toll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, and macrophages, and appears to play a central role in mediating both the antiviral and inflammatory responses of the innate immunity in combating viral infections.
Chicken TLR3 protein shows 61% identity to human TLR3.
The chicken ortholog of mammalian TLR3 specifically recognizes poly I:C, a dsRNA analogue, like its mammalian counterpart. In the chicken as in mammals, poly I:C rapidly induces type 1 IFN.
|GO Biological Process||toll-like receptor 3 signaling pathway (0034138)|
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|18202435||Sensing of viral infection and activation of innate immunity by toll-like receptor 3||Clin Microbiol Rev||2008|
|15733829||Transcriptional signaling by double-stranded RNA: role of TLR3||Cytokine Growth Factor Rev||2005|