Reactome: A Curated Pathway Database

TLR3 cascade

Stable Identifier
R-GGA-434048
Type
Pathway
Species
Gallus gallus
Locations in the PathwayBrowser
Summation

Toll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, and macrophages, and appears to play a central role in mediating both the antiviral and inflammatory responses of the innate immunity in combating viral infections.

Chicken TLR3 protein shows 61% identity to human TLR3.

The chicken ortholog of mammalian TLR3 specifically recognizes poly I:C, a dsRNA analogue, like its mammalian counterpart. In the chicken as in mammals, poly I:C rapidly induces type 1 IFN.

Literature References
Participants
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