Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Syk/Lck phosphorylate LAT
Stable Identifier
R-HSA-434836
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
Syk/Lck phosphorylate LAT (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated Syk (or possibly the related kinase Lck) phosphorylates two key tyrosine residues of LAT.
Literature References
PubMed ID
Title
Journal
Year
16938345
Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes
Jiang, Y
,
Cheng, H
Leuk Res
2007
Participants
Input
x 2
ATP [cytosol]
LAT [plasma membrane]
(Homo sapiens)
Output
x 2
ADP [cytosol]
p-Y200,Y220-LAT [plasma membrane]
(Homo sapiens)
Participates
as an event of
GPVI-mediated activation cascade (Homo sapiens)
Catalyst Activity
protein tyrosine kinase activity of p-Y348-SYK/LCK [cytosol]
Physical Entity
p-Y348-SYK/LCK [cytosol]
(Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Syk/Lck phosphorylate LAT (Bos taurus)
Syk/Lck phosphorylate LAT (Canis familiaris)
Syk/Lck phosphorylate LAT (Mus musculus)
Syk/Lck phosphorylate LAT (Rattus norvegicus)
Syk/Lck phosphorylate LAT (Sus scrofa)
Authored
Akkerman, JW (2009-09-04)
Reviewed
Harper, MT (2009-11-02)
Poole, AW (2009-11-02)
Jones, ML (2009-11-02)
Created
Jupe, S (2009-09-03)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text