Reactome: A Curated Pathway Database

Syk/Lck phosphorylate LAT (R-HSA-434836)

Species Homo sapiens


Activated Syk (or possibly the related kinase Lck) phosphorylates two key tyrosine residues of LAT.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , plasma membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
SYK/LCK protein tyrosine kinase activity (0004713)
Literature References
pubMedId Title Journal Year
16938345 Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes Leuk Res 2007