Reactome: A Curated Pathway Database

Zinc transporters (R-HSA-435354)

Species Homo sapiens


Zinc is an essential element for all organisms because it serves as a catalytic or structural cofactor for many different proteins. Cellular zinc homoeostasis is co-ordinated through Zn2+-specific transporters which are members of two distinct gene families. Members of the SLC39 gene family (ZRTL-like import proteins1-14, ZIP1-14) are responsible for Zn2+ import into the cytoplasm, either across the plasma membrane or out of intracellular organelles. In contrast, members of the SLC30 gene family (zinc transporters 1-10, ZnT1-10) export Zn2+ from the cytoplasm, either across the plasma membrane into the extracellular space or into intracellular organelles (Murakami M and Hirano T, 2008; Devirgiliis C et al, 2007; Eide DJ, 2006).

Locations in the PathwayBrowser
Literature References
pubMedId Title Journal Year
17374385 Zinc fluxes and zinc transporter genes in chronic diseases Mutat Res 2007
16675045 Zinc transporters and the cellular trafficking of zinc Biochim Biophys Acta 2006
18754861 Intracellular zinc homeostasis and zinc signaling Cancer Sci 2008